Flurbiprofen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs), it works by reducing hormones that cause inflammation and pain in the body. Flurbiprofen is prescribed to treat pain or inflammation caused by arthritis and dysmenorrhea among other medical conditions.
Warnings and Important Information
Flurbiprofen can cause circulatory or serious heart problems, such as heart attack or stroke, especially if used long term. Do not use flurbiprofen just before or after coronary bypass surgery.
Seek emergency medical attention if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.
This medication can cause serious effects on the stomach or intestines, including bleeding or perforation, these conditions can be fatal and can occur without warning, especially in older adults. Call your doctor immediately if you have symptoms of bleeding in your stomach.
Do not use this medication if you are allergic to flurbiprofen, or if you have:
severe kidney disease, or
a history of allergic reaction to aspirin or other NSAIDs.
If you have any of these other conditions, your doctor may need to adjust your dose of flurbiprofen:
a history of heart attack, stroke, or blood clot;
heart disease, congestive heart failure, hypertension;
history of stomach ulcers or bleeding;
liver or kidney disease;
polyps in your nose;
a bleeding or blood clotting, or
if you smoke.
Tell your doctor if you are pregnant or plan to become pregnant during treatment, take flurbiprofen during the last 3 months of pregnancy may harm the unborn baby. Do not take flurbiprofen during pregnancy unless your doctor has told you to.
Flurbiprofen can pass into breast milk and may harm a nursing baby.
Do not give this medication to a child without the advice of a doctor.
Ask your doctor or pharmacist before using any other medicine for a cold allergy, or pain medication. Many medicines available over the counter contain medicines similar to flurbiprofen as aspirin, ibuprofen, ketoprofen, or naproxen.
Avoid drinking alcohol as it can increase your risk of stomach bleeding.
How to take it
Take Flurbiprofen exactly as prescribed by your doctor, do not take in larger or smaller amounts or for longer than recommended.
The maximum amount of flurbiprofen for adults is 400 mg per day.
If you take flurbiprofen for a long period of time, your doctor may want to check regularly to make sure this medication is not causing harmful effects, do not miss any scheduled appointments.
Store Flurbiprofen at room temperature away from moisture, heat, and light.
Dosage in Adults
Osteoarthritis: 50 mg orally 4 times daily or 100 mg orally 3 times a day. The highest recommended single dose is 100 mg. Doses greater than 300 mg per day are not recommended.
Rheumatoid arthritis: 50 mg orally 4 times daily or 100 mg orally 3 times a day. The highest recommended single dose is 100 mg. Doses greater than 300 mg per day are not recommended.
Pain: 50 mg orally every 6-8 hours as needed for pain relief. The maximum daily dose should not exceed 300 mg.
Dysmenorrhea: 50 mg orally 4 times a day.
Seek emergency medical attention if you have any of these signs of an allergic reaction to flurbiprofen: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.
Stop taking flurbiprofen and seek medical attention or call your doctor at once if you have any of these serious side effects:
chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
black stools, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;
urinating less than usual or not at all;
pain, burning or bleeding when you urinate;
swelling, rapid weight gain;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash, or
bruising, severe tingling, numbness, pain, muscle weakness.
Less serious side effects of flurbiprofen include:
upset stomach, mild heartburn or stomach pain, diarrhea, constipation, bloating, gas;
dizziness, headache, nervousness;
itching or rash;
increased sweating, runny nose;
blurred vision, or
ringing in the ears.
This is not a complete list of side effects and others may occur, call your doctor for medical advice about side effects.
Interactions with other medicines
Tell your doctor if you are taking an antidepressant such as citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline or venlafaxine. Taking any of these drugs with flurbiprofen may cause you to bruise or bleed easily.
Tell your doctor about all other medications you use, especially:
a blood thinner such as warfarin;
a diuretic such as furosemide;
aspirin or other NSAIDs such as ibuprofen, diclofenac, etodolac, indomethacin, meloxicam, nabumetone, naproxen, piroxicam, and others;
ACE inhibitor such as benazepril, enalapril, lisinopril, quinapril, ramipril, and others, or
a beta-blocker such as atenolol, carvedilol, labetalol, metoprolol, nadolol, propranolol, sotalol or other.
This list is not complete and other drugs may interact with flurbiprofen, tell your doctor about all other medications you use, this includes over-the-counter medicines, vitamins, and herbs. Do not start using a new medication without telling your doctor.